Tadapox (Tadalafil/Dapoxetine)

Drug Info

• Brand Name: Tadapox;
• Active Ingredient: Tadalafil/Dapoxetine;
• Manufacturer: Centurion Laboratories.

Tadapox and its drug substances Tadalafil/Dapoxetine

The new combination drug Tadapox (Tadalafil/Dapoxetine) has become a real breakthrough in the treatment of sexual disorders. The pharmacological action is due to two active substances, which have a different mechanism of action, but are intended for improvement of sexual function.

Tadalafil works by increasing the activity of one of the chemical substances (nitric oxide) that the body releases in the penis during sexual arousal. As a result of this action, a number of biochemical and hemodynamic changes happen:

• The three arteries of the penis are dilated;
• Blood flow is increased (blood outflow is temporarily restricted);
• One spongy and two cavernous bodies of the penis are filled with blood;
• The penis increases in size (the phase of a full and hard erection is reached).

The mechanism of action of Dapoxetine is related with an increase in the level and activity of serotonin in the CNS. High activity of serotonin in the brain leads to:

• Improving control over ejaculation;
• Increasing the time it takes to ejaculate.

Indications for use

Tadapox is used for treatment of a variety of problems related with male sexual function:

• Premature ejaculation;
• Weak erection after sexual arousal;
• Weakening of erection during sexual intercourse;
• Complete inability to achieve an erection.

The drug is prescribed for various types of above disorders, including psychogenic, organic or mixed ones.

Treatment regimens and dosages

This drug is supplied in the form of tablets for oral use. There is only one dosage form of Tadapox available on the market. Each Tadapox tablet contains Tadalafil 20 mg + Dapoxetine 60 mg.

The standard Tadapox dosage regimen for adults:

• The safe daily dose is 80 mg (1 tablet);
• Take a tablet at least 30–60 minutes before sex;
• If you want to be 100 % ready for sex, take Tadapox 1–3 hours before it.

To get an erection when taking Tadapox, any form of sexual stimulation is required. This drug does not cause sexual desire and does not affect male libido.

Recommendations for use

For best results from Tadapox and guaranteed elimination of sexual dysfunction, follow these recommendations:

• Don't take the pills more than once a day;
• Don't chew or crush the tablets, take them whole;
• Take Tadapox 80 mg with a full glass of water;
• Don't use the drug after a fatty meal, as this can delay its effect.

You can take Tadapox 80 mg only once a day, since the effect of Dapoxetine lasts about 10–12 hours, and the effect of Tadalafil can last up to 36 hours.

Missed Dose

Take a dose of Tadapox 80 mg as needed before sex, no more than once a day.

Precautions

Before taking Tadapox, it is recommended to consult a doctor, if you have or have previously had health problems such as:

• Severe depression;
• Heart attack or stroke within the past six months;
• Moderate or severe liver diseases;
• Serious valvular heart diseases;
• Optic neuropathy.

Don't take alcohol with Tadapox, as this can cause increased dizziness, drowsiness, blurred vision, etc.

Use of Tadapox during pregnancy

Tadapox is not intended for the treatment of female sexual disorders. It should not be taken by women, including those who are pregnant or breastfeeding.

Possible side effects

The following side effects are relatively common when using Tadapox:

• Insomnia;
• Drowsiness;
• Headache;
• Face redness;
• Tinnitus.

At the same time, any of these effects has a mild form and does not cause severe complications. After a few days of regular use of Tadapox, side effects disappear.

Tadalafil and Dapoxetine: interaction with other drugs

Important information: If you are taking Tadapox 80 mg or any other ED drug, never use nitrates (vasodilators). This can lead to a big drop in blood pressure, an attack of hypotension and coma.

Various types of interactions (not always serious) may happen, if you use this medicine with:

• Drugs acting on the central nervous system (hypnotics, antipsychotics, antidepressants, etc.);
• Antifungals such as Ketoconazole (Nizoral) or Itraconazole (Lozanoc);
• Antiretroviral drugs such as Ritonavir (Norvir, Kaletra).

Storage

Store in a dry place at a room temperature ranging from 15°C to 25°C. Exposure to ultraviolet rays, moisture or heat can adversely affect the therapeutic properties of the drug.

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